Low-Dose Naltrexone for Depression, Anxiety, and PTSD
How It Works

The Taub Group - Charlotte, NC
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How LDN is Different for
Treating Depression, Anxiety, and PTSD

Low-dose naltrexone (LDN) produces an unusual rebound effect improving the way the body handles its own endorphins in three ways. Endorphins are natural hormones that inhibit pain signals and upregulate mood. Cells have specific receptors to receive endorphins called OGFrs. LDN blocks OGFrs from working for a couple of hours before the body eliminates the naltrexone. In response to the block, the body starts working harder to make endorphins work again.

  1. The body increases endorphin production.
  2. The cells produce more endorphin receptors (OGFrs).
  3. The body increases the sensitivity of the OGFrs. While LDN blocks endorphins for about two hours, the body's endorphin-enhancing response lasts about a day.

The rebound effect is why low-dose naltrexone works for depression, PTSD, and anxiety symptoms but higher doses or timed-released doses don't. It's the limited time of the endorphin block that creates the increase in quantity and effectiveness of the body's own endorphins.

To find out if this or other breakthrough behavioral health treatments would be a good option for you, please call now to schedule an appointment: (704) 442-9805

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LDN Safety
Naltrexone is an FDA-approved drug that is not generally considered addictive. Some people discontinuing LDN may experience headaches and low energy similar to a caffeine withdrawal. LDN can be used in combination with some medications, but other meds may need to be discontinued. Inform your doctor of all drugs you are taking so combinations can be planned appropriately.
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