Low-dose naltrexone (LDN) produces an unusual rebound effect improving the way the body handles its own endorphins in three ways. Endorphins are natural hormones that inhibit pain signals and upregulate mood. Cells have specific receptors to receive endorphins called OGFrs. LDN blocks OGFrs from working for a couple of hours before the body eliminates the naltrexone. In response to the block, the body starts working harder to make endorphins work again.

1. The body increases endorphin production.
2. The cells produce more endorphin receptors (OGFrs).
3. The body increases the sensitivity of the OGFrs. While LDN blocks endorphins for about two hours, the body's endorphin-enhancing response lasts about a day.

The rebound effect is why low-dose naltrexone works for depression, PTSD, and anxiety symptoms but higher doses or timed-released doses don't. It's the limited time of the endorphin block that creates the increase in quantity and effectiveness of the body's own endorphins.

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